Report
Alcohol Use During Pregnancy And Child Neurodevelopment

Author
Jane L Halliday (e-mail: janehalliday.h@mcri.edu.au), Evelyne Muggli, Sharon Lewis, Elizabeth J Elliott, David J Amor, Colleen O’Leary, Susan Donath, Della Forster, Cate Nagle, Jeffrey M Craig, Peter J Anderson
Citation
Halliday JL, Muggli E, Lewis S, et al Alcohol consumption in a general antenatal population and child neurodevelopment at 2 years J Epidemiol Community Health Published Online First: 24 August 2017. doi: 10.1136/jech-2017-209165
  • Source
    BMJ Journal of Epidemiology and Community Health
  • Release date
    24/08/2017

Alcohol consumption in a general antenatal population and child neurodevelopment at 2 years

Research report

Abstract

Background

Prenatal alcohol exposure (PAE) is a community health problem with up to 50% of pregnant women using alcohol. The relationship between low or sporadic binge PAE and adverse child outcomes is not clear.

This study examines the association between PAE in the general antenatal population and child neurodevelopment at 2 years, accounting for relevant contributing factors.

Methods

This prospective population-based cohort recruited 1570 pregnant women, providing sociodemographic, psychological and lifestyle information and alcohol use for five time periods. PAE categories were ‘low’, ‘moderate/high’, ‘binge’, in trimester 1 or throughout pregnancy. Measures of cognitive, language and motor development (Bayley Scales of Infant and Toddler Development) were available for 554 children, while measures of sensory processing (Infant/Toddler Sensory Profile) and social–emotional development (Brief Infant Toddler Social Emotional Assessment) were available for 948.

Results

A positive association in univariate analysis with low-level PAE throughout pregnancy and cognition (β=4.1, 95% CI −0.02 to 8.22, p=0.05) was attenuated by adjusting for environmental/social deprivation risk factors (β=3.06 (−1.19 to 7.30), p=0.16). Early binge alcohol use, plus continued PAE at lower levels, was associated with the child being more likely to score low in sensation avoidance (adjusted OR 1.88 (1.03 to 3.41), p=0.04).

Conclusion

Early binge exposure, followed by lower-level PAE, demonstrated an increase in sensation-avoiding behaviour. There were, however, no significant associations between PAE and neurodevelopment following adjustment for important confounders and modifiers. Follow-up is paramount to investigate subtle or later onset problems.

Source Website: BMJ Journals