Report
Maternal Substance Use During Pregnancy And Offspring Conduct Problems

Author
I.Hyun Ruisch, Andrea Dietrich, Jeffrey C. Glennon, Jan K. Buitelaar, Pieter J. Hoekstra
Citation
I.Hyun Ruisch, Andrea Dietrich, Jeffrey C. Glennon, Jan K. Buitelaar, Pieter J. Hoekstra: Maternal substance use during pregnancy and offspring conduct problems: a meta-analysis, in: Neuroscience & Biobehavioral Reviews, August 2017, https://doi.org/10.1016/j.neubiorev.2017.08.014
  • Source
    Neuroscience & Biobehavioral Reviews
  • Release date
    25/08/2017

Maternal substance use during pregnancy and offspring conduct problems: a meta-analysis

Review Article

Highlights

  1. Pregnancy smoking and alcohol use are associated with offspring conduct problems.
  2. Findings also suggest a stronger effect in clinical samples.
  3. The researcher report no clear effects of cannabis and caffeine, but studies were few.
  4. Causality issues due to shared genetic and social factors need to be addressed.

Abstract

We conducted meta-analyses of relationships between highly prevalent substance use during pregnancy and offspring conduct disorder problems. In total 36 studies were included. Odds ratios (ORs) were 2.06 (1.67–2.54, 25 studies) for maternal smoking, 2.11 (1.42–3.15, 9 studies) for alcohol use, and 1.29 (0.93–1.81, 3 studies) for cannabis use, while a single study of caffeine use reported no effects.

The researchers’ meta-analyses support an association between smoking and alcohol use during pregnancy, and offspring conduct problems, yet do not resolve causality issues given potential confounding by genetic factors, gene-environment interactions, and comorbidity such as with attention deficit hyperactivity disorders.

Future studies should use genetically sensitive designs to investigate the role of pregnancy substance use in offspring conduct problems and may consider more broadly defined behavioral problems.

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