Scientific Article
Neurobiological and Cognitive Profile of Young Binge Alcohol Users

Author
Briana Lees (email: briana.lees@sydney.edu.au), Louise Mewton, Lexine A. Stapinski, Lindsay M. Squeglia, Caroline D. Rae and Maree Teesson
Citation
Lees, B., Mewton, L., Stapinski, L.A. et al. Neuropsychol Rev (2019). https://doi.org/10.1007/s11065-019-09411-w
  • Source
    Neuropsychology Review
  • Release date
    11/09/2019

Neurobiological and Cognitive Profile of Young Binge Drinkers: a Systematic Review and Meta-Analysis

Research article

Abstract

Introduction

This review provides the first systematic and quantitative synthesis of the literature examining the relationship between binge alcohol use, cognition, brain structure and function in youth aged 10 to 24 years.

Method

PubMed, EMBASE, Medline, PsychINFO and ProQuest were searched for neuroimaging, neurophysiological, and neuropsychological studies. A total of 58 studies (21 neuroimaging, 16 neurophysiological, 21 neuropsychological) met the eligibility criteria and were included in the review.

Results

Overall, abnormal or delayed development of key frontal executive-control regions may predispose youth to binge alcohol use. These abnormalities appear to be further exacerbated by the uptake of binge alcohol use, in addition to alcohol-related neural aberrations in reward-seeking and incentive salience regions, indexed by cognitive deficits and maladaptive alcohol associations. A meta-analysis of neuropsychological correlates identified that binge alcohol use in youth was associated with a small overall neuro-cognitive deficit (g = −0.26) and specific deficits in decision-making (g = −1.70), and inhibition (g = −0.39). Using the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) Evidence Profile, the certainty in outcomes ranged from very low to low.

Conclusion

Future prospective longitudinal studies should address concomitant factors, exposure thresholds, and age-related vulnerabilities of binge alcohol use, as well as the degree of recovery following discontinuation of use.

Source Website: Springer